Purpose. To evaluate navigated laser photocoagulation for the treatment of refractory diabetic macular edema (DME). Methods.\nRetrospective study of 25 eyes (21 patients) treated with Navilas 577+ focal laser system. Best-corrected visual acuity (BCVA)\nand spectral-domain optical coherence tomography (OCT) parameters were measured at baseline, 1, 3, and 6 months, and final\nvisit. Results. The mean follow-up period was 12.8 Ã?± 2.4 (7ââ?¬â??16 months). All subjects had history of previous treatment which\nwas injection of triamcinolone acetonide or antivascular endothelial growth factor (VEGF) agents. The navigated laser\nphotocoagulation was delivered to the microaneurysms on indocyanine green angiography (ICGA) in 21 of 25 eyes (84%),\nfluorescein angiography (FA) guided in 3 eyes, and OCT angiography guided in 1 eye. After initial navigated laser treatment, 16\nof 25 eyes (64%) were needed additional navigated laser photocoagulation, injection of triamcinolone acetonide, and/or injection\nof VEGF agents. Although median BCVA remained stable, the central retinal thickness and macular volume were significantly\ndecreased over 6 months (p < 0 05). All patients were treated without complications. Conclusions. Focal photocoagulation using\nNavilas 577+ showed to be effective in treating DME with improvement in macular edema on OCT over 6 months. Navilas 577+\nwas beneficial to perform navigated laser photocoagulation based on three modalities (ICGA, FA, and OCT angiography).
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